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A taillored service for your needs
Enhance drug discovery with our bespoke services utilizing the Caenorhabditis elegans model. Leverage tailored assays for efficient and precise drug discovery, from evaluating efficacy to elucidating mechanisms of action. Our solutions are designed to meet your specific requirements, ensuring comprehensive and reliable scientific advancements. Partner with us to propel your research into new frontiers with accuracy and innovation.
Drug safety at organism level
Elevate your drug safety research with advanced assays using Caenorhabditis elegans. Our methodologies provide comprehensive insights:
Brood Size Assay: Assess the impact of compounds on reproductive capacity by quantifying offspring production.
Health Assay: Examine qualitative parameters such as morphological changes, locomotion, and overall health.
Heat Shock Response Assay: Measure the survival rate post-heat stress exposure in the presence of test compounds.
Food Clearance Assay: Evaluate the rate of bacterial consumption to determine effects on feeding behavior.
Harness the advantages of C. elegans for cost-effective, high-throughput, and insightful drug safety testing. Propel your research with precision and innovation.
Drug efficacy in disease
Transform your approach to drug efficacy testing with Caenorhabditis elegans. By utilizing its genetic and biological similarities to human systems, C. elegans plays a crucial role in assessing treatments for a range of conditions.
Neuromuscular Disorders: Assess the efficacy of pharmaceutical compounds by analyzing changes in muscle function and locomotion.
Neurodegenerative Conditions: Investigate treatments by introducing specific genetic mutations and observing impacts on neuron function and behavior.
Aging and Longevity: Explore anti-aging interventions aimed at extending lifespan and improving healthspan.
Metabolic Disorders: Evaluate the effects of drugs on metabolic processes and regulatory mechanisms.
Oncological Studies: Study tumor growth, metastasis, and cellular responses to anticancer drugs, enhancing cancer research.
Infectious Diseases: Test antimicrobial compounds by examining host-pathogen interactions, providing critical insights for infectious disease research.
In vivo mechanism of action determination
Caenorhabditis elegans is an invaluable model organism for elucidating the mechanisms of action of pharmacological agents in vivo due to its genetic tractability and biological relevance to human systems.
Genetic Manipulation: The introduction of specific genetic mutations or the use of transgenic strains facilitates the investigation of drug effects on targeted genes or pathways.
Fluorescent Reporters: Utilizing fluorescent markers allows for the real-time visualization of protein activity and cellular processes, thereby providing insights into the pharmacodynamics of compounds.
Behavioral Assays: The observation of alterations in behaviors such as locomotion, feeding, and reproduction aids in the assessment of drug impact on physiological functions.
Biochemical Assays: Quantifying biochemical markers, including reactive oxygen species (ROS) and stress response proteins, elucidates cellular responses to pharmacological treatments.
High-Throughput Screening: The capacity to culture large populations of C. elegans supports automated, high-throughput screening, enabling the efficient identification of drugs with specific mechanisms of action.